Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone - Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity (EN)

Kovala-Demertzi, D. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)

Kovala-Demertzi, D. (EN)

An interesting series of new platinum complexes has been synthesized by the reaction of Na(2)ptCl(4) with 2-acetyl pyridine thiosemicarbazone, HAcTsc. The new complexes, [Pt(AcTsc)CI], [Pt(HAcTsc),]Cl-2 and [Pt(AcTsc)(2)], have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complex [Pt(AcTsc)CI] has been solved by single-crystal X-ray diffraction. The anion of HAcTsc coordinates in a planar conformation to the central platinum(II) through the pyridyl N, azomethine N and thiolato S atoms. Double intermolecular hydrogen bonds (NH-CI), pi-pi and weak Pt-Pt and Pt-pi contacts lead to aggregation and to a two-dimensional supramolecular assembly. The antibacterial and antifungal effect of the novel platinum(II) complexes and the related palladium(fl) complexes, [Pd(AcTsc)CI], [d(HAcTsc),]Cl, and [Pd(AcTsc),], were studied in vitro. The complexes were found to have a completely lethal effect on Gram+ bacteria, while the same complexes showed no bactericidal effect on Gram- bacteria. Additionally, the complexes [Pt(AcTsc),] and [Pd(AcTsc),] showed effective antifungal activity towards yeast. Among these compounds [33], the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(AcTsc)(2)] while the rest, display marginal cytogenetic and antitumour effects. (C) 2001 Elsevier Science BY All rights reserved. (EN)

platinum(ii) complex (EN)

Πανεπιστήμιο Ιωαννίνων

Ιδρυματικό Αποθετήριο Ολυμπιάς

Σχολή Θετικών Επιστημών

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"

Τμήμα Χημείας

J Inorg Biochem (EN)

Αγγλική γλώσσα

2001

http://olympias.lib.uoi.gr/jspui/handle/123456789/8882

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