Revisiting bleomycin from pathophysiology to safe clinical use

 
This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*
share



2013 (EN)
Revisiting bleomycin from pathophysiology to safe clinical use (EN)

Froudarakis, M. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Froudarakis, M. (EN)

Bleomycin is a key component of curative chemotherapy regimens employed in the treatment of curable cancers, such as Hodgkin lymphoma (HL) and testicular germ-cell tumours (GCT), yet its use may cause bleomycin-induced lung injury (BILI), which is associated with significant morbidity and a mortality rate of 1-3%. Diagnosis of BILI is one of exclusion and physicians involved in the care of HL and GCT patients should be alerted. Pharmacogenomic studies could contribute towards the identification of molecular predictors of bleomycin toxicity on the aim to optimize individual use of bleomycin. We review all existing data on bleomycin's most recent integrated chemical biology, molecular pharmacology and mature clinical data and provide guidelines for its safe clinical use. (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Crit Rev Oncol Hematol (EN)

English

2013


Elsevier (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)