Sequential oligopetide carriers, SOCn, as scaffolds for the reconstitution of antigenic proteins: applications in solid phase immunoassays

 
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2004 (EN)
Sequential oligopetide carriers, SOCn, as scaffolds for the reconstitution of antigenic proteins: applications in solid phase immunoassays (EN)

Sakarellos-Daitsiotis, M. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Sakarellos-Daitsiotis, M. (EN)

A new class of helicoid type sequential oligopeptide carriers (SOC), for anchoring antigenic epitopes, has been modeled from the repetitive Lys-Aib-Gly (SOCn-I) and Aib-Lys-Aib-Gly (SOCn-II) units aiming to the development of scaffolds with predetermined 3D structures. Conformational analysis showed that the SOCn carriers adopt 3(10)-helical structures, while the SOCn-conjugates retain their original active conformations and they interact neither to the carriers nor to each other. It is concluded that the helicoid structure of SOC,, helps the reconstitution and/or mimicking of the native forms of the epitopes so that potent antigens are generated for developing specific, sensitive and reproducible immunoassays. (C) 2003 Elsevier B.V. All rights reserved. (EN)

oligopeptide carriers (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

J Pharm Biomed Anal (EN)

English

2004

<Go to ISI>://000220237600005

Elsevier (EN)



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