Smoking induces lipoprotein-associated phospholipase A(2) in cardiovascular disease free adults: The ATTICA Study

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2009 (EN)
Smoking induces lipoprotein-associated phospholipase A(2) in cardiovascular disease free adults: The ATTICA Study (EN)

Tselepis, A. D. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Tselepis, A. D. (EN)

Objectives: We studied the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) mass and activity with various lifestyle, clinical and biochemical characteristics in cardiovascular disease (CVD) free adults. Background: Lipoprotein-associated phospholipase A(2) is a novel biomarker of inflammation and risk for CVD. The Lp-PLA(2) mass and activity are primarily influenced by the plasma levels of low-density lipoprotein (LDL), however, the influence of various lifestyle characteristics on Lp-PLA(2) have not been adequately studied. Methods and results: In a random sub-sample of 186 subjects, 64 men (52 +/- 13 years) and 122 women (48 +/- 13 years) from the ATTICA Study (Greece), LP-PLA(2) activity and mass in total plasma as well as the enzyme activity and mass associated with high-density lipoprotein (HDL-Lp-PLA(2)) were determined using established methods. Several socio-demographic, lifestyle, clinical and biochemical parameters were assessed in all participants. Multiple linear regression analysis revealed that among the lifestyle characteristics, total plasma Lp-PLA(2) activity and mass were positively and independently associated with current smoking (p = 0.02 and p = 0.05, respectively), as well as with exposure to second-hand smoke (p = 0.02 and p = 0.01, respectively). Furthermore, HDL-Lp-PLA(2) activity and mass were inversely and independently associated with current smoking (p = 0.04 and p = 0.09, respectively). Conclusions: Smoking is associated with and might even induce an increase in proatherogenic total plasma Lp-PLA(2), but attenuates antiatherogenic HDL-Lp-PLA(2). These results further support the role of smoking as an important avoidable cause of CVD. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (EN)

atherosclerosis (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Atherosclerosis (EN)



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Elsevier Ireland (EN)

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