Solid state and solution studies of a vanadium(III)-L-cysteine compound and demonstration of its antimetastatic, antioxidant and inhibition of neutral endopeptidase activities

 
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Πανεπιστήμιο Ιωαννίνων
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Ιδρυματικό Αποθετήριο Ολυμπιάς
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Solid state and solution studies of a vanadium(III)-L-cysteine compound and demonstration of its antimetastatic, antioxidant and inhibition of neutral endopeptidase activities (EN)

Papaioannou, A. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Papaioannou, A. (EN)

Reaction of one equivalent of vanadium(III) chloride with three equivalents Of L-cysteine(H(2)Cys) in methyl alcohol affords a V-III-Cys compound that is formulated as [V-III(HCYS)(3)] . 2HCl . 2.5H(2)O 1. The solid state characterization of 1 was performed by microanalysis, circular dichroism (CD) and infrared studies as well as room temperature magnetic susceptibility. These studies have shown coordination of each HCys(-) ligand to the V-III atom through an amine nitrogen and a carboxylate oxygen atoms. Solution studies of I were carried out in water and methanol by UV visible, CD and electron paramagnetic resonance (EPR) spectroscopies. According to these studies, it was evident that despite the progressive oxidation of 1 to oxovanadium(IV) species, some V(III) species were also present in solution after several hours. Compound 1, (VOSO4)-O-IV.5H(2)O and L-cysteine were examined for their total antioxidant capacity (TAC) and lag time. Compound 1 exhibited significantly greater total antioxidant capacity and lag time values than L-cysteine. (VOSO4)-O-IV.5H(2)O did not show any total antioxidant capacity or lag time. The inhibition of neutral endopeptidase (NEP) activity caused by 1, (VOSO4)-O-IV . 5H(2)O and thiorphan was also measured. Compound 1, at a concentration of 10(-3) M, showed inhibition of NEP activity as potent as thiorphan at 10(-6) M, while (VOSO4)-O-IV . 5H(2)O in the same concentration exhibited less than 50% inhibitory activity than that of thiorphan at 10-6 M. Moreover, the antimetastatic effects of compound 1, L-CySteine and (VOSO4)-O-IV . 5H(2)O were examined on Wistar rats, treated with 3,4-benzopyrene. The results revealed that I prevents significantly lung metastases (only 9.5% of animals treated with 1 showed metastases), whereas 47-52% of the rats of the control group and those treated with L-cysteine and (VOSO4)-O-IV . 5H(2)O exhibited metastases. (C) 2004 Elsevier Inc. All rights reserved. (EN)

vanadium (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

J Inorg Biochem (EN)

Αγγλική γλώσσα

2004

<Go to ISI>://000221939000006

Elsevier (EN)



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