Stray Cu(II) may cause oxidative damage when coordinated to the -TESHHK- sequence derived from the C-terminal tail of histone H2A

 
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2001 (EN)
Stray Cu(II) may cause oxidative damage when coordinated to the -TESHHK- sequence derived from the C-terminal tail of histone H2A (EN)

Mylonas, M. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Mylonas, M. (EN)

CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a hexapeptide representing the 120-125 sequence of histone H2A, coordinates Cu(II) ions efficiently. Monomeric complexes are formed. In the major complex at physiological pH, CuH-1L, Cu(II) is coordinated equatorially through the imidazole nitrogen of the His-4 residue and the amide nitrogens of the Ser-3 and His-4 residues, and axially through the imidazole nitrogen of the His-5 residue. This complex reacts with H2O2 and the resulting reactive oxygen intermediate efficiently oxidizes 2 ' -deoxyguanosine. The underlying mechanism involves the formation of Cu(III) and a metal-bound hydroxyl radical species. (EN)

copper(ii) complexes (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Chem Res Toxicol (EN)

English

2001

<Go to ISI>://000171153800004

American Chemical Society (EN)



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