Structural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactions

 
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Structural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactions (EN)

Lazarou, K. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Lazarou, K. (EN)

Direct reaction of copper(I) chloride with triphenylphosphine (tpp) in molar ratio 2: 3 and 1: 3, results in the formation of the [(tpp)Cu(mu(2)-Cl)(2)Cu(tpp)(2)] (1) and {[CuCl(tpp)(3)]center dot(CH(3)CN)} (2) complexes. The complexes have been characterized by melting point, FT-IR, UV-Vis spectroscopic data and X-ray crystallography. Complex 1 is di-nuclear. Two mu(2)-Cl atoms bridge two copper(I) ions with tetrahedral and trigonal geometry respectively. The short copper-copper bond distance of 2.9039(6) angstrom in case of 1 indicates d(10)-d(10) interaction between metal centers. Thus, our studies were extended here in the determination of the quasi-aromaticity, which results in strong Cu-Cu interactions, using the computational method of nucleus-independent chemical shifts (NICS). The NICS calculated at the inner region of the Cu(2)Cl(2)P(3) core in complex 1 is shielded up to -6.05 ppm. Complex 2 is mono-nuclear where three phosphorus and one chloride atoms form a tetrahedron around the copper(I) ion. Photolysis of both complexes 1 and 2, results in the formation of triphenylphosphine oxide. The complexes 1 and 2, were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7). The type of LMS cell death caused by the complexes was also evaluated by use of a flow cytometry assay. The results show that at concentration of 5 mu M of complexes 1 and 2, 34.1% (1) and 19.6 (2)% of LMS cells undergo programmed cell death (apoptosis), while at 10 mu M, 80.4% (1) and 65.2% (2) of LMS cells undergo apoptosis. The light sensitivity of the complex is discussed in relation with the biological activity. (C) 2009 Elsevier B. V. All rights reserved. (EN)

bioinorganic chemistry (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Inorganica Chimica Acta (EN)

Αγγλική γλώσσα

2010

<Go to ISI>://000274414700018

Elsevier (EN)



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