Synthesis and characterisation of the first organotin complex of piroxicam. An extended network system via non-hydrogen, hydrogen bonding linkages and C-H center dot center dot center dot pi contacts

 
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1999 (EN)
Synthesis and characterisation of the first organotin complex of piroxicam. An extended network system via non-hydrogen, hydrogen bonding linkages and C-H center dot center dot center dot pi contacts (EN)

Hadjikakou, S. K. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Hadjikakou, S. K. (EN)

The organotin complex, [SnBu2(pir)](n), of the potent and widely used anti-inflammatory drug piroxicam, H(2)pir, was obtained and a crystal structure determination showed that in this complex the ligand is doubly deprotonated at the oxygen and amide nitrogen atoms. There are two similar molecules in the asymmetric unit. The isolated molecules of Sn(1) or Sn(2) are arranged in polymers in a head to tail fashion with a stacking of alternate parallel chains. Extended networks of Sn-O-Sn, C-H ... O and C-H ...pi contacts lead to aggregation and a supramolecular assembly. Real concentration protonation constants for the zwitterionic form (pyridyl group) and the protonated piroxicam (enolic group) were determined spectrophotometrically in pure aqueous solutions of constant ionic strength. It is the first example where piroxicam is proved to act as a doubly deprotonated tridentate ligand. (EN)

crystal-structure (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Journal of the Chemical Society-Dalton Transactions (EN)

English

1999

<Go to ISI>://000079211700006

Royal Society of Chemistry (EN)



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