Synthesis and characterization of a new chloro-di-phenyltin(IV) complex with 2-mercapto-nicotinic acid: Study of its influence upon the catalytic oxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase
Synthesis and characterization of a new chloro-di-phenyltin(IV) complex with 2-mercapto-nicotinic acid: Study of its influence upon the catalytic oxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase
(EN)
Xanthopoulou, M. N.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
Xanthopoulou, M. N.
(EN)
The complex [(C6H5)(2)SnCl(HMNA)] (1) where H(2)MNA is thioamide 2-mercapto-nicotinic acid has been synthesized by reacting a methanolic solution of di-chloro-di-phenyltin(IV) Ph2SnCl2 with an aqueous solution of 2-mercapto-nicotinic acid, containing twofold amount of potassium hydroxide. The Sn/ligand molar ratio is 2:1. The complex was characterized by elemental analysis, FT-IR and Mossbauer spectroscopic techniques. In addition the crystal structure of the molecule was determined by all X-ray diffraction at 293(2) K. C18H14ClNO2SSn is monoclinic, space group P2(1)/n, a = 15.089(3) angstrom, b = 15.846(3) angstrom, c = 16.691(3) angstrom, beta = 105.57(3)degrees, Z = 8. The ligand coordinates to the metal center through the exocyclic sulfur and the heterocyclic nitrogen atoms, forming a four membered ring. The coordination sphere around the tin(IV) ion is completed with two carbon atoms from the two phenyl groups and one chlorine atom. The geometry around the tin atom can be described either as trigonal bipyramidal or tetragonal pyramidal. Finally, the influence of the complex [(C6H5)(2)SnCl(HMNA)] (1) upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was also kinetically and theoretically studied and the results compared with the ones of the corresponding binuclear complex [(C6H5)(3)Sn(MNA)Sn(C6H5)(3) (acetone)] (2) reported in the literature. (c) 2005 Elsevier B.V. All rights reserved.
(EN)
