Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes

 
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1998 (EN)
Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes (EN)

Kokotos, G. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Kokotos, G. (EN)

A number of lipophilic platinum(II) complexes of the general structures cis-[Pt(LA)(2)Cl-2] and [Pt(LD)Cl-2] were synthesised. Long chain amines (LA) and diamines (LD), prepared from lipidic amino acids, were used as ligands. The in vitro cytotoxicity of the complexes was evaluated against four cell lines (P388, NSCLC-N6, E39, M96). cis-Dichloro-bis(2-aminohexadecanol)platinum(II) was the most active against P388, NSCLC-N6 and E39 (IC50: 11 mu g/ml, 25 mu g/ml, 31 mu g/ml), while dichloro(1,3-heptadecanediamine)platinum presented the highest activity against M96 (IC50: 13 mu g/ml). (C) 1998 Elsevier Science Ltd. All rights reserved. (EN)

lipidic amino-acids (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Bioorganic and Medicinal Chemistry Letters (EN)

English

1998

<Go to ISI>://000074291800017

Elsevier (EN)



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