Synthesis of a proline-rich [60]fullerene peptide with potential biological activity

 
This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*
share



2004 (EN)
Synthesis of a proline-rich [60]fullerene peptide with potential biological activity (EN)

Sofou, P. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Sofou, P. (EN)

A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product 8 as a TFA salt, with oxidized methionine. Product 8 was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment). (C) 2004 Elsevier Ltd. All rights reserved. (EN)

fullerenes (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Tetrahedron (EN)

English

2004

<Go to ISI>://000220257900011

Elsevier (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)