Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants

 
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2012 (EN)
Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants (EN)

Georgiou, D. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Georgiou, D. (EN)

The 1,3-dipolar cycloaddition to N-phenylmaleimide of azomethine ylides, generated in situ from sulfanyl-substituted imines of glycine esters, yields 5H-dihydro-pyrrolo products with syn diastereoselectivity. The syn (major) and anti (minor) products were isolated chromatographically and fully characterized by spectroscopic methods and in two cases also by X-ray analysis. The diastereomeric cycloadducts were tested for their antioxidant activity with good results. (C) 2012 Elsevier Ltd. All rights reserved. (EN)

azomethine ylides (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Bioorganic and Medicinal Chemistry (EN)

English

2012

<Go to ISI>://000307828600005

Elsevier (EN)



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