Synthesis of the 2,3-epoxide of the 2,3-dimethylbenzo[b]furan, the proposed ultimate mutagen of the benzofuran dioxetanes

 
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1991 (EN)
Synthesis of the 2,3-epoxide of the 2,3-dimethylbenzo[b]furan, the proposed ultimate mutagen of the benzofuran dioxetanes (EN)

Adam, W. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Adam, W. (EN)

Dioxetanes can be precursors for mutagenic epoxides"”this provocative hypothesis is the result of this study. Epoxidation of the benzofurans 1 with dimethyldioxirane and deoxygenation of the benzofuran dioxetanes 3 with dimethyl sulfides allows for the first time the synthesis of labile furanepoxides 2. Compounds 2 and 3 are strongly mutagenic in the histidine-auxotrophic Salmonella typhimurium strain TA 100. X = H, Ac. (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Angewandte Chemie International Edition in English (EN)

English

1991




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