Synthesis, characterization and biological studies of new antimony(III) halide complexes with Ο‰-thiocaprolactam
(EN)
Ozturk, I. I.
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
Ozturk, I. I.
(EN)
Three new antimony(III) halide complexes (SbX3, X = Cl, Br and I) with the heterocyclic thione Ο‰-thiocaprolactam (1-azacycloheptane-2-thione, (Hthcl)) of formulae {[SbCl2(ΞΌ2-Cl)(Hthcl)2]n} (1), {[(SbBr2(ΞΌ2-Br)(Hthcl)2)2]} (2) and {[(SbI2(ΞΌ2-I)(Hthcl)2)2]} (3) were synthesized from the reaction of antimony(III) halides with Ο‰-thiocaprolactam in 1:2 stoichiometry. The complexes were characterized by elemental analysis, FT-IR spectroscopy, 1H, 13C NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Crystal structures of the ligand Ο‰-thiocaprolactam and its complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1-3 and Ο‰-thiocaprolactam were evaluated for their in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) tumor cell lines. Antimony complexes 1-3 exhibit strong antiproliferative activity against both cell lines tested. The higher such activity was found for 3 with IC50 values of 0.12 Β± 0.04 ΞΌM (LMS) and 0.76 Β± 0.16 ΞΌM (MCF-7) which are 60 and 10 times respectively, stronger than that of cisplatin. The influence of these complexes 1-3 and Ο‰-thiocaprolactam upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The results were shown negligible inhibitory activity of 1-3 against LOX.
(EN)
