Synthesis, spectroscopic studies, and crystal structures of phenylorganotin derivatives with [bis(2,6-dimethylphenyl)amino]benzoic acid: Novel antituberculosis agents (EN)

Dokorou, V. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)

Dokorou, V. (EN)

The novel triphenyl adduct of 2-[(2,6-dimethylphenyl)amino]benzoic acid (HDMPA; 1), i.e., [SnPh3(DMPA)] (2), the dimeric tetraorganostannoxane [Ph-2(DMPA)SnOSn(DMPA)Ph2]2 (3), and the monomeric adduct [SnPh2(DMPA)(2)] (4), where DMPA is monodeprotonated HDMPA, have been prepared and structurally characterized by means of IR, H-1-NMR, and C-13-NMR spectroscopy. The structures of 1 and 2 have been determined by X-ray crystallography. Single-crystal X-ray-diffraction analysis of 1 revealed that there are two molecules in the asymmetric unit, HD1 and HD2, differing in conformation, both forming centrosymmetric dimers linked by H-bonds between the carboxylic O-atoms. X-Ray analysis of 2 revealed a pentacoordinate structure containing Ph3Sn coordinated to the carboxylato group. Significant C-H/pi interactions and intramolecular H-bonds stabilize the structures of 1 and 2, which self-assembled via C-H/pi and pi/pi-stacking interactions. The Ph3Sn adduct 2 was found to be a promising antimycobacterial lead compound, displaying activity against Mycobacterium tuberculosis H37Rv. The cytotoxiciy in the Vero cell line is also reported. (EN)

penta-coordinated structures (EN)

Πανεπιστήμιο Ιωαννίνων

Ιδρυματικό Αποθετήριο Ολυμπιάς

Σχολή Θετικών Επιστημών

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"

Τμήμα Χημείας

Helvetica Chimica Acta (EN)

Αγγλική γλώσσα

2004

http://olympias.lib.uoi.gr/jspui/handle/123456789/9512

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