Synthesis, Structural Characterization, and Computational Studies of Novel Diiodine Adducts with the Heterocyclic Thioamides N-Methylbenzothiazole-2-thione and Benzimidazole-2-thione:"‰ Implications with the Mechanism of Action of Antithyroid Drugs
Synthesis, Structural Characterization, and Computational Studies of Novel Diiodine Adducts with the Heterocyclic Thioamides N-Methylbenzothiazole-2-thione and Benzimidazole-2-thione:"‰ Implications with the Mechanism of Action of Antithyroid Drugs
(EN)
G.J. Corban,
(EN)
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
(EL)
G.J. Corban,
(EN)
The reaction of I2 with N-methylbenzothiazole-2-thione and benzimidazole-2-thione produced three new charge-transfer complexes. The X-ray crystal structure of {[(MBZIM)2I]+}Β·[I3-}Β·[(MBZIM)I2] reveals the cocrystallization of both a "�spoke"� and an "�iodonium"� salt. This is the first such crystal structure ever reported and may lead to the conclusion that a "�spoke"� and an iodonium salt equilibrium may also be established in solution. Useful conclusions on the mechanism of action of antithyroid drugs are drawn.
(EN)
