The Antiplatelet and Antithrombotic Actions of Statins

This item is provided by the institution :
University of Ioannina
Repository :
Repository of UOI Olympias
see the original item page
in the repository's web site and access all digital files if the item*

2010 (EN)
The Antiplatelet and Antithrombotic Actions of Statins (EN)

Mitsios, J. V. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Mitsios, J. V. (EN)

Several studies over the last years have demonstrated that statins exhibit actions beyond that of lipid-lowering (pleiotropic effects) ranging from improving endothelial function, modulating the inflammatory response, maintaining plaque stability and preventing thrombus formation. Since the interplay among platelets, cells and other components of atherosclerotic lesions as well as the coagulation system play an important role in the progression of atherosclerosis and in the development of acute coronary syndromes, these non-lipid properties of statins may help to explain the early and significant reduction of cardiovascular events reported in several clinical trials of statin therapy. This review focuses on the experimental and clinical results regarding the antiplatelet/antithrombotic effects of statins. (EN)

atherosclerosis (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Curr Pharm Des (EN)



<Go to ISI>://000286877500004

*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)