Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

 
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2006 (EN)
Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes (EN)

Malandrinos, G. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Malandrinos, G. (EN)

Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis. (EN)

2-(alpha-hydroxyethyl)thiamin pyrophosphate hetpp (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Chemical Society Reviews (EN)

English

2006

<Go to ISI>://000239211500002

Royal Society of Chemistry (EN)



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