Towards the characterization of squalene synthase activity in extracts of Zymomonas mobilis

 
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1996 (EN)
Towards the characterization of squalene synthase activity in extracts of Zymomonas mobilis (EN)

Koukkou, A. I. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Koukkou, A. I. (EN)

Extracts of Zymomonas mobilis in the presence of NADPH converted tritium-labelled farnesyl diphosphate (FPP) into squalene, resulting from the activity of squalene synthase, as well as diploptene and diplopterol, derived from further squalene cyclisation. An unidentified isoprenoid representing up to 70% of the conversion products of FPP and different from presqualene alcohol was also formed, even in the absence of NADPH. Addition of squalestatin 1, an inhibitor of squalene synthase, blocked biosynthesis from FPP of the three former triterpenes, in accordance with the role of squalene synthase in their formation, as well as that of the unknown compound. (EN)

zymomonas mobilis (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

FEMS Microbiol Lett (EN)

English

1996

<Go to ISI>://A1996UX51900028

Wiley-Blackwell (EN)



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