Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85

 
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2000 (EN)
Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85 (EN)

Tselios, T. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Tselios, T. (EN)

In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP72-85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Alas(81)MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP72-85 and cyclo(2-9)MBP72-85. (C) 2000 Elsevier Science Ltd. All rights reserved. (EN)

peptide analogs (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Bioorg Med Chem Lett (EN)

English

2000

<Go to ISI>://000165849700006

Elsevier (EN)



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