Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine

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2007 (EN)
Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine (EN)

Xanthopoulou, M. N. (EN)

Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας (EL)
Xanthopoulou, M. N. (EN)

The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bu2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1-4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2-4 was demonstrated. (EN)

bioinorganic chemistry (EN)

Πανεπιστήμιο Ιωαννίνων (EL)
University of Ioannina (EN)

Russian Chemical Bulletin (EN)



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Springer (EN)

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