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Cutaneous amyloidosis in a patient with systemic amyloidosis due to multiple myeloma

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National and Kapodestrian University of Athens, Postgraduate Program "Intensive Care Units"   

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Cutaneous amyloidosis in a patient with systemic amyloidosis due to multiple myeloma (EN)
Vallianou, Natalia
Jahaj, Edison
Kounatidis, Dimitris
Panagopoulos, Fotis
Papaodyssea, Ioanna
Stamatopoulos, Vasilis
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2024-04-02
Cutaneous manifestations in systemic amyloidosis secondary to multiple myeloma or AL amyloidosis are seen in approximately 15%-40% of patients with systemic amyloidosis. Cutaneous involvement has a preference for skin folds, retroauricular region, eyelids, neck and the axilla and may present in the form of purpura, domed papules or nodes resembling isolated nodular amyloidosis. Congo red staining remains the gold standard for diagnosis, revealing amyloid fibrils with apple-green birefringence in the polarized microscopy. It is noteworthy that patients may sometimes present with non-specific skin changes, suggestive of depositional disease, such as alopecia or nail dystrophy. Herein, we present a patient with systemic amyloidosis, who exhibited red-brown macules coalescing into a rippled pattern in the extremities, amyloid nodules in the peri-auricular region and dystrophic nails, findings that were attricuted to cutaneous amyloidosis in the context of systemic amyloidosis. (EN)
cutaneous (EN)
systemic (EN)
erythema (EN)
Amyloidosis (EN)
dystrophic nails (EN)
Health and Research Journal
English
Postgraduate Program "Intensive Care Units" National and Kapodistrian University of Athens (EN)
2459-3192
Health & Research Journal; Τόμ. 10 Αρ. 2 (2024): Volume 10 Issue 2 April - June 2024; 116-118 (EL)
Health & Research Journal; Vol. 10 No. 2 (2024): Volume 10 Issue 2 April - June 2024; 116-118 (EN)
Copyright (c) 2024 Health & Research Journal (EN)
National and Kapodestrian University of Athens, Postgraduate Program "Intensive Care Units"
Health and Research Journal
Case Report



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