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The clinical significance of occult HBV infection

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Hellenic Society of Gastroenterology   

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Annals of Gastroenterology   

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The clinical significance of occult HBV infection (EN)
Raimondo, Giovanni
Spinella, Rosaria
Squadrito, Giovanni
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2013-12-04
The presence of hepatitis B virus (HBV) DNA in HBV surface antigen (HBsAg)-negative individuals is defined as occult HBV infection (OBI). OBI is related in some cases to infection with variant viruses (S-escape mutants) undetectable by HBsAg commercial kits. More frequently, however, it is due to infection with wild-type viruses that are strongly suppressed in their replication activity. OBI may be involved in different clinical contexts, including the transmission of the infection by blood transfusion or liver transplantation and its acute reactivation when an immunosuppressive status occurs. Moreover, much evidence suggests that it may contribute to the development of cirrhosis and may have an important role in hepatocarcinogenesis.Keywords Hepatitis B virus, occult hepatitis B virus infection, hepatitis B virus transmission, hepatitis B virus reactivation, cirrhosis, hepatocellular carcinomaAnn Gastroenterol 2014; 27 (1): 15-19 (EN)
English
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 27, No 1 (2014); 15 (EN)
Hellenic Society of Gastroenterology
Annals of Gastroenterology
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