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      "@value" : "SUMMARY\nThe last decade has been marked by substantial progress\nin the understanding of the pathophysiology of Irritable\nBowel Syndrome (IBS). Considerable advances contributing\nto this progress include the decryption of the secrets of\nthe enteric nervous system (ENS) and the neuronal pathways\ninvolved in the transmission of visceral nociception\nas well as the localisation of potential processing centres\nin the central nervous system (CNS). Serotonin is sequestered\nin the neterochromaffin cells and is an essential mediator\nin the ENS. It manifests its actions mainly by 5-HT3\nand 5-HT4 receptors and plays a key role in intestinal motility\nand secretion. The “central processing unit” of serotoninergic\nactions in the ENS is the AH/Dogiel morphologic\ntype II neuron which was formerly considered to be the\nprimary afferent neuron. It remains unknown whether the\nneurologic disorder in IBS consists of an exaggerated response\nto noxious stimuli in the gut, or misinterpretation\nby the CNS of otherwise accurate information. The exact\nlocus of projection of visceral information in the brain is\nnot known, but there is increasing evidence for areas such\nas the thalamus, the prefrontal cortex and the amygdaloid\nnucleous in the limbic system. Anxiogenic colonic response\nis probably mediated by CRF-1 receptors. Autonomic pathways\nfrom the brain stem may also play a role by regulating\nthe intensity of perception during visceral stimulation.\nMore accurate localisation of the neurologic derangement\nalong the brain-gut axis is required, thus permitting a more\ntargeted therapeutic intervention.\nGastroenterology department, Tzaneion Hospital, Pireus, Greece    Key words: Serotonin, visceral nociception, affered neuron\npresynaptic inhibition"
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