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      "@value" : "SUMMARY\nThe gut constitutes the main reservoir of the body’s serotonin.\nThe latter has effects not only on colonic motility via\nactivation of cholinergic or nitric oxide-dependent neurons\nbut also on the modulation of sensation by excitation of\nintrinsic sensory neurons. The abundance of serotonin receptors\nwithin the enteric nervous system constituted a challenge,\nas the pharmacological intervention on these receptors\ncould be the etiological treatment of Irritable Bowel\nSyndrome (IBS). 5-HT3 and 5-HT4 are the main subtypes of\nserotonin receptors in the gut. Therapeutic blockade of 5-\nHT3 by alosetron in women with diarrhea- predominant IBS\nbrought a revolution in the treatment of IBS. This drug acts\nboth on colonic motility and the secretory function of the\nbowel but, despite the spectacular results, it had to be withdrawn\ndue to 49 cases of ischemic colitis. 5-HT4 agonists\nhave been used for the treatment of patients with constipation-\nprone IBS. In large comparative trials tegaserod was\nmore effective than placebo although the therapeutic gain\nover placebo was small. Prucalopride is a potent 5-HT4 agonist\nbut much concern has been raised by the report of\ncarcinogenicity in animals. Other serotonergic modulators\ninclude piboserod (SB207266) and MKC 733 but no clinical\ntrials in humans are available. Sumatriptan, a 5-HT1B/D\nagonist developed for the treatment of migraine, causes relaxation\nof the gastric fundus in man, but its intranasal administration\nlimits its use. As abdominal pain constitutes\nthe main complaint of IBS patients, future efforts must concentrate\non medications acting on visceral hypersensivity.   Key words: Alosetron, colonic motility ivisceral hypersensivity\nischemic coliti"
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