Ogura, YasuhiroKamei, HideyaIshigami, MasatoshiIshizu, YojiHori, TomohideOnishi, YasuharuKurata, NobuhikoHepatitis C recurrence continues to present a major challenge in liver transplantation (LT). Approximately 10% of hepatitis C virus (HCV)-positive recipients will develop fibrosing cholestatic hepatitis (FCH) after LT. FCH is clinically characterized as marked jaundice with cholestatic hepatic dysfunction and high titers of viremia. Pathologically, FCH manifests as marked hepatocyte swelling, cholestasis, periportal peritrabecular fibrosis and only mild inflammation. This progressive form usually involves acute liver failure, and rapidly results in graft loss. A real-time and precise diagnosis based on histopathological examination and viral measurement is indispensable for the adequate treatment of FCH. Typical pathological findings of FCH are shown. Currently, carefully selected combinations of direct-acting antivirals (DAAs) offer the potential for highly effective and safe regimens for hepatitis C, both in the pre- and post-transplant settings. Here, we review FCH caused by HCV in LT recipients, and current strategies for sustained virological responses after LT. Only a few cases of successfully treated FCH C after LT by DAAs have been reported. The diagnostic findings and therapeutic dilemma are discussed based on a literature review.Keywords Fibrosing cholestatic hepatitis, hepatitis C, liver transplantation, intractable ascites, portal hypertensionAnn Gastroenterol 2016; 29 (4): 454-459text/htmlapplication/pdfimage/jpeghttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/2716engHellenic Society of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 29, No 4 (2016); 454Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2016-09-29Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.Επιστημονικό άρθροScientific articleΒιβλιοκρισία / ΒιβλιοπαρουσίασηBook reviewΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other