{ "@graph" : [ { "@id" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/EKT-voc-classifier/1368266523", "exactMatch" : [ "http://id.loc.gov/authorities/subjects/sh85053479", "http://semantics.gr/authorities/EKT-voc/657834409" ], "note" : { "@language" : "en", "@value" : "isi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum." }, "prefLabel" : [ { "@language" : "en", "@value" : "Gastroenterology" }, { "@language" : "el", "@value" : "Γαστροεντερολογία" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/Issue-segment", "prefLabel" : [ { "@language" : "en", "@value" : "Publication in journal" }, { "@language" : "el", "@value" : "Δημοσίευση σε περιοδικό" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/arthro", "prefLabel" : [ { "@language" : "en", "@value" : "Scientific article" }, { "@language" : "el", "@value" : "Επιστημονικό άρθρο" } ] }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/aggregation/provider/000025-2743%231", "@type" : "ore:Aggregation", "aggregatedCHO" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-2743", "dataProvider" : "Ελληνική Γαστροεντερολογική Εταιρία", "isShownAt" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743", "provider" : "Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)", "rights" : "other" }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-2743", "@type" : "edm:ProvidedCHO", "creator" : [ "Saif, Muhammad Wasif", "Garcon, Marie C.", "Relias, Valerie", "Jiang, Zhenyang", "Rodriguez, Teresa", "Butler-Bowen, Harriet", "Hennessey Smith, Melissa" ], "description" : { "@language" : "en", "@value" : "Background Fatigue is a common but devastating symptom for advanced pancreatic cancer (APC) patients. To date, no proven treatment exists. Methylphenidate (MPH) showed inconsistent results in treating other cancer related fatigue. We performed a retrospective study to assess MPH in ameliorating fatigue in APC patients.Methods We retrospectively reviewed our clinic APC patients' records who visited from 06/2011 - 11/2014. Fatigue was assessed by Visual Analog Fatigue Scale (VAFS) and classified as grade 1 (VAFS 1-3), grade 2 (VAFS 4-6) and grade 3 (VAFS 7-10) to correspond with CTCAE V4.0. MPH was dosed at 5 mg daily in the morning and was escalated to 10 mg after 2 weeks if needed. The primary endpoint was to assess the change of fatigue grade after 4 weeks of MPH. Secondary outcomes included MPH's effect on depression, anorexia, maintenance chemotherapy intensity and adverse effects.Results A total of 71 APC patients on concomitant chemotherapy were included, of whom 67% received doublet, 13% triplet, and 20% single-agent chemotherapy. Mean baseline VAFS was 7, which dropped to 4 after 4 weeks of MPH, 55% patients' fatigue score improved by 1 grade, 8% by 2 grades, 23% had fatigue resolved, 14% without benefit. 72% patients maintained chemotherapy intensity, 39% felt less depression and 52% had improved appetite. 13% stopped MPH due to side effects. Rare Grade 3 or 4 adverse events included insomnia, restlessness, palpitations and anorexia.Conclusions Our findings support low-dose MPH benefits APC patients with improved fatigue, depression and anorexia. A large randomized clinical trial is needed to confirm its usage and safety.Keywords Methylphenidate, fatigue, pancreatic cancer, chemotherapy, cachexiaAnn Gastroenterol 2016; 29 (4): 536-543" }, "format" : [ "text/html", "application/pdf", "application/vnd.openxmlformats-officedocument.wordprocessingml.document" ], "identifier" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743", "language" : "eng", "publisher" : { "@language" : "en", "@value" : "Hellenic Society of Gastroenterology" }, "relation" : [ "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743/1839", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743/3658", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743/1838", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2743/3722" ], "source" : [ { "@language" : "en", "@value" : "Annals of Gastroenterology; Volume 29, No 4 (2016); 536" }, "1792-7463", "1108-7471" ], "subject" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "title" : { "@language" : "en", "@value" : "Role of methylphenidate in the treatment of fatigue in advanced pancreatic cancer population" }, "type" : [ "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "http://semantics.gr/authorities/openarchives-item-types/Scientific-article" ], "dc:type" : [ "info:eu-repo/semantics/article", "info:eu-repo/semantics/publishedVersion" ], "created" : "2016-09-29" } ], "@context" : { "source" : { "@id" : "http://purl.org/dc/elements/1.1/source" }, "type" : { "@id" : "http://purl.org/dc/elements/1.1/type", "@type" : "@id" }, "creator" : { "@id" : "http://purl.org/dc/elements/1.1/creator" }, "publisher" : { "@id" : "http://purl.org/dc/elements/1.1/publisher" }, "format" : { "@id" : "http://purl.org/dc/elements/1.1/format" }, "relation" : { "@id" : "http://purl.org/dc/elements/1.1/relation", "@type" : "@id" }, "created" : { "@id" : "http://purl.org/dc/terms/created" }, "language" : { "@id" : "http://purl.org/dc/elements/1.1/language" }, "description" : { "@id" : "http://purl.org/dc/elements/1.1/description" }, "title" : { "@id" : "http://purl.org/dc/elements/1.1/title" }, "subject" : { "@id" : "http://purl.org/dc/elements/1.1/subject", "@type" : "@id" }, "identifier" : { "@id" : "http://purl.org/dc/elements/1.1/identifier" }, "broader" : { "@id" : "http://www.w3.org/2004/02/skos/core#broader", "@type" : "@id" }, "prefLabel" : { "@id" : "http://www.w3.org/2004/02/skos/core#prefLabel" }, "note" : { "@id" : "http://www.w3.org/2004/02/skos/core#note" }, "exactMatch" : { "@id" : "http://www.w3.org/2004/02/skos/core#exactMatch", "@type" : "@id" }, "rights" : { "@id" : "http://www.europeana.eu/schemas/edm/rights" }, "provider" : { "@id" : "http://www.europeana.eu/schemas/edm/provider" }, "isShownAt" : { "@id" : "http://www.europeana.eu/schemas/edm/isShownAt", "@type" : "@id" }, "dataProvider" : { "@id" : "http://www.europeana.eu/schemas/edm/dataProvider" }, "aggregatedCHO" : { "@id" : "http://www.europeana.eu/schemas/edm/aggregatedCHO", "@type" : "@id" }, "ore" : "http://www.openarchives.org/ore/terms/", "owl" : "http://www.w3.org/2002/07/owl#", "svcs" : "http://rdfs.org/sioc/services#", "skos" : "http://www.w3.org/2004/02/skos/core#", "rdfs" : "http://www.w3.org/2000/01/rdf-schema#", "rdaGr2" : "http://rdvocab.info/ElementsGr2/", "edm" : "http://www.europeana.eu/schemas/edm/", "ekt" : "https://www.semantics.gr/authorities/schemanamespaces/ekt#", "doap" : "http://usefulinc.com/ns/doap#", "rdf" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#", "xalan" : "http://xml.apache.org/xalan", "dcterms" : "http://purl.org/dc/terms/", "wgs84_pos" : "http://www.w3.org/2003/01/geo/wgs84_pos#", "foaf" : "http://xmlns.com/foaf/0.1/", "crm" : "http://www.cidoc-crm.org/rdfs/cidoc_crm_v5.0.2_english_label.rdfs#", "dc" : "http://purl.org/dc/elements/1.1/" } }