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      "@value" : "Hepatitis C virus (HCV) is considered the principal etiologic\nagent of post-transfusion hepatitis and is the main\ncause of chronic liver disease in multi-transfused subjects.\nTransfusion-associated HCV infection has become rare\nsince blood donor screening was initiated in 1990.\nThere is an impressively wide range of anti-HCV(+) prevalence\nin thalassemics worldwide. This range varies from\n2.7% to 97%. Studies in the early 90s report higher anti-\nHCV rates compared to studies after 1993 when anti-HCV\nscreening was largely available in transfusion centres. However\nlarge differences in anti-HCV(+) between centers in\nthe same country seem to need further explanation.\nHCV genotype distribution also varies significantly between\ncountries and between thalassemia centres within the same\ncountry. In studies from Asian countries, it seems that HCV\ninfection genotypes 3 and 6 predominate. In studies from\nEurope there is a genotype 1 predominance, while in Greece\nit seems that genotype 3 predominates.\nPatients with â-thalassemia in Northwest Greece have an\nHCV seroprevalence of 22.7% which is the lowest described\nin Greece, while serum HCV-RNA was not detectable in the\nmajority (74%) of HCV(+) patients. No HCV(+) patient\nwas co-infected with HIV, HBV, HSV1, HSV2 and CMV.\nHCV-RNA was detectable in 4 (26%) patients and\ntransaminasemia was frequent (73%).\nAlpha-interferon (a-IFN) is the first-line treatment for\nthalassemic patients diagnosed with HCV infection. There\nis, therefore, particular clinical importance to determine\nthe incidence of HCV infection in thalassemic patients in\norder to facilitate monitoring and treatment policy.\nKey words: HCV infection, thalassemia, prevalence, HCVRNA,\nanti-HCV(+)."
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