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      "@value" : "Hepatic ischemia/reperfusion-induced injury is accompanied\nby free radical production, leading to endothelial cell\ndestruction, adhesion of neutrophils and plugging of the\nhepatic sinusoids and thus to blood microcirculation flow\nreduction. Naloxone is a known opioid antagonist that has\nbeen shown to act by inhibiting the release of free radicals.\nThe purpose of this study is to clarify the changes in\nhepatic microcirculation during liver ischemia and after\nreperfusion in the rat and the potential beneficial effects\nof Naloxone as pretreatment, in respect to microcirculation\nand oxidative stress.\nOne hundred and forty male Wistar rats, allocated to\nNaloxone [N] or Placebo [P] treatment, were subjected\nto either 30min or 60min normothermic ischemia [70% of\ntotal liver], followed by 60min reperfusion. Liver microcirculation\nwas assessed by laser-Doppler flowmetry at\nbaseline, at the end of the ischemia period [30min or\n60min, respectively] and at the end of the reperfusion period,\nwhile oxidative stress was assessed by means of MDA\nat the same time periods.\nNaloxone pretreatment seemed to protect liver parenchyma,\nsince MDA levels were significantly decreased in relation\nto placebo treated rats, in both 30min ischemia/\n60min reperfusion and 60min ischemia/60min reperfusion\ngroups. Similarly, Naloxone pretreatment was found to\nsignificantly improve liver microcirculation in relation to\nplacebo treated rats, in both groups.\nIn conclusion, the results of this study indicate that\nNaloxone pretreatment protects the liver from ischemia/\nreperfusion hepatocellular injury.\nKey words: Naloxone, ischemia/reperfusion injury, liver, laser-\nDoppler flowmetry, malondialdehyde"
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