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Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis

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Ελληνική Γαστροεντερολογική Εταιρία   

Αποθετήριο :
Annals of Gastroenterology   

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Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis (EN)
Konstantakis, Christos
Gogos, Charalambos
Thomopoulos, Konstantinos
Karatzas, Andreas
Triantos, Christos
Tsiaoussis, Georgios
Koukias, Nikolaos
Kalogeropoulou, Christina
Kalafateli, Maria
Koutroubakis, Efstratios
Tselekouni, Paraskevi
Assimakopoulos, Stelios
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2018-07-02
Background Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis.The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and itsprognostic value in this setting. Methods In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival. Results Body mass index: median 26 (range 17-45.2); model for end-stage liver disease (MELD) score: median 11 (6-29); Child-Pugh (CP) score: median 7 (5-13), CP class: A=49 (50.5%), B=39 (40%), C=10 (9.5%); hepatocellular carcinoma: 14 (14.3%); follow up: median 45 (1-140) months. Median L4 total psoas area (TPA): 2022 (777-3806) mm2; L4 average total psoas density (ATPD): 42.52 (21.26- 59.8) HU. ATPD was significantly correlated with age (r=-0.222, P=0.034), creatinine (r=-0.41, P<0.001), albumin (r=0.224, P=0.035), MELD score (r=-0.218, P=0.034), and TPA (r=0.415, P<0.001). Fifty-four patients (55.1%) died during follow up. In the multivariate analysis, higher CP score (hazard ratio [HR] 1.2, 95% confidence interval [CI] 1.04-1.41), advanced age (HR 1.038, 95%CI 1.006-1.07) and lower ATPD (HR 0.967, 95%CI 0.937-0.997) were predictors of mortality. Conclusion Muscle fat infiltration, as a result of sarcopenia, is a negative predictive factor of survival in cirrhosis, emphasizing the need for early identification of this subgroup of patients. Keywords Sarcopenia, nutrition, analytic morphometry Ann Gastroenterol 2018; 31 (4): 491-498 (EN)
Αγγλική γλώσσα
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 31, No 4 (2018); 491 (EN)
Copyright (c) 2018 Annals of Gastroenterology (EN)
Ελληνική Γαστροεντερολογική Εταιρία
Annals of Gastroenterology
Original Articles



*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.