Cuyle, Pieter-JanPrenen, HansNeuroendocrine tumors are heterogeneous, rare malignancies that arise most frequently in the gastroenteropancreatic tract (GEPNET). The therapeutic armamentarium for the treatment of GEPNETs has expanded significantly over the last two decades, however the ideal sequencing strategy remains controversial. As this disease may be relatively slow-growing, patients are expected to be treated for longer periods, so that even mild toxicities can influence quality of life, compliance and outcome in the long run. Prospective data on optimal adverse event management are lacking and recommendations are largely based on expert opinion and drug prescribing information. This review summarizes practical recommendations for toxicity management associated with the most commonly used GEPNET treatment options and stresses important focus points for future clinical trials. Keywords Neuroendocrine tumor, somatostatin analogue, peptide receptor radionucleotide therapy, interferon-α, everolimus, sunitinib, toxicity management Ann Gastroenterol 2018; 31 (2): 140-150text/htmlapplication/pdfhttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/3729engHellenic Society of GastroenterologyCopyright (c) 2018 Annals of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 31, No 2 (2018); 140Practical management of toxicities associated with targeted therapies for advanced gastroenteropancreatic neuroendocrine tumorsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2018-03-05Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.Επιστημονικό άρθροScientific articleΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other