Deutsch, MelanieKontogianni, Meropi D.Yannakoulia, MaryPapatheodoridis, Georgios V.Papageorgiou, Maria-VasilikiPapadopoulos, NikolaosGeorgiou, AlexandraAlexopoulou, AlexandraIoannidou, PanagiotaVlachogiannakos, IoannisBackground Accurate assessments of muscle mass in patients with cirrhosis are necessary in clinical practice. Computed tomography (CT) of the upper abdomen has been proposed as a useful method for quantifying muscle mass. Recently, Carey et al developed specific cutoffs for muscle wasting based on the skeletal muscle index at the L3 vertebra (L3-SMI) for cirrhotic patients. The aim of the present study was to assess the concurrent validity of the newly proposed cutoffs of Carey et al, along with others widely used in several clinical contexts, using dual energy X-ray absorptiometry (DXA) as the reference method. Methods Data were evaluated from 97 Caucasian patients (59.8% male, 59.1±11.6 years old, 45.4% decompensated) with cirrhosis of various etiologies. Muscle mass was assessed using the appendicular lean mass index (ALMI) by DXA and the L3-SMI by CT. Low L3-SMI was defined in relation to 5 different cutoffs. Results Low muscle mass prevalence was 13.4% according to ALMI and 26.8-45.4% according to the different cutoffs applied for L3-SMI. The Carey et al, Prado et al and Montano-Loza et al cutoffs showed similar sensitivity (all 69.2%) and specificity (79.8%, 76.2% and 75.0%, respectively) and high accuracy (78.4%, 75.3% and 74.2%). The Carey et al cutoffs showed the highest diagnostic validity against DXA: the multivariate odds ratio adjusted for age, sex, body mass index category, disease etiology and model for end-stage liver disease score (95% confidence interval) was 5.88 (1.36-25.4), P=0.018. Conclusion Compared to DXA, the cutoffs for identifying muscle wasting proposed by Carey et al were proven to be the most accurate. Keywords Cirrhosis, muscle mass, muscle wasting, DXA, computed tomography Ann Gastroenterol 2020; 33 (1): 80-86text/htmlapplication/pdfhttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/4784engHellenic Society of GastroenterologyCopyright (c) 2019 Annals of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 33, No 1 (2020); 80Validation of cutoffs for skeletal muscle mass index based on computed tomography analysis against dual energy X-ray absorptiometry in patients with cirrhosis: the KIRRHOS studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2019-12-27Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.Επιστημονικό άρθροScientific articleΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other