Perrea P.,Adamis S.,Grigoriou Th.,Sechas M.,Fotiadis C., .Pilichos H., .Xekouki P.,Perrea D.,Pilichos H.,Papalois A.,Karayannakos P.,Papalois A., .Leventis J.,Fotinou M.,Karampela E.,Preza A.,Poussios D., .Galanis G.,SUMMARY The aminoacid L-Arginine being the sole donor of nitric oxide synthesis in cases of intestinal ischemia, seems to play a protective role during experimental acute colon ischemia and reperfusion. We studied the effect of pretreatment with the aminoacid L-arginine in 144 Wistar rats who were subjected to experimental acute ischemic colitis (A.I.C.) and reperfusion of varying time periods (30, 60, 90 minutes). L-arginine was studied in comparison with Molcydomine and Caseine, two substances used for intestinal protection. Serum malondialdehyde (MDA) levels, a reliable marker which indicate the degree of tissue damage after ischemia-reperfusion, were lower in the L-arginine group, while the same group presented the lower level of histopathological damages. We conclude that pretreatment with L-arginine in rats subjected to A.I.C. attenuates the histopathophysiological damages. Key words: L-Arginine, Reperfusion injury, Intestinal ischemia, Malondialdehyde, Experimental model.application/pdfhttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/53engHellenic Society of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 14, No 1 (2001)The prophylactic effect of L-Arginine in an experimental model of acute ischemic colitis. A histopathological and biochemical (malondialdehyde levels) evaluationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2007-03-19Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.Επιστημονικό άρθροScientific articleΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other