{ "@graph" : [ { "@id" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/EKT-voc-classifier/1368266523", "exactMatch" : [ "http://id.loc.gov/authorities/subjects/sh85053479", "http://semantics.gr/authorities/EKT-voc/657834409" ], "note" : { "@language" : "en", "@value" : "isi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum." }, "prefLabel" : [ { "@language" : "en", "@value" : "Gastroenterology" }, { "@language" : "el", "@value" : "Γαστροεντερολογία" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/Issue-segment", "prefLabel" : [ { "@language" : "en", "@value" : "Publication in journal" }, { "@language" : "el", "@value" : "Δημοσίευση σε περιοδικό" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/arthro", "prefLabel" : [ { "@language" : "en", "@value" : "Scientific article" }, { "@language" : "el", "@value" : "Επιστημονικό άρθρο" } ] }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/aggregation/provider/000025-5321%231", "@type" : "ore:Aggregation", "aggregatedCHO" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-5321", "dataProvider" : "Ελληνική Γαστροεντερολογική Εταιρία", "isShownAt" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/5321", "provider" : "Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)", "edm:rights" : "other" }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-5321", "@type" : "edm:ProvidedCHO", "creator" : [ "Asghar, Muhammad", "Shoaib, Hasan", "Kim, MinChul", "Walayat, Saqib", "Dhillon, Sonu" ], "description" : { "@language" : "en", "@value" : "Background The American Association for the Study of Liver Diseases recommends that N-acetylcysteine (NAC) may be beneficial in non-acetaminophen-related drug-induced liver injury. A subsequent review and analysis reported the current evidence to be inconclusive. Herein, we present an updated review and meta-analysis.\nMethods We evaluated prospective, retrospective and randomized controlled trials that compared outcomes in patients of all ages with acute liver failure (defined as abnormal liver enzymes along with elevated international normalized ratio >1.5, with or without hepatic encephalopathy) receiving NAC with the outcomes in a control group. The primary outcome was to compare the overall survival in the 2 groups. Secondary outcomes included difference in length of hospital stay, transplant-free survival, and post-transplant survival.\nResults Seven studies (N=883) that met the inclusion criteria were included in this analysis. The mean age of patients in the NAC group was 21.22 years compared with 23.62 years in the control group. The odds of overall survival were significantly higher in the NAC group than in controls (odds ratio [OR] 1.77, 95% confidence interval [CI] 1.3-2.41). Post-transplant survival (OR 2.44, 95%CI 1.11-5.37) and transplant-free survival were also better in the NAC group than in the control group (OR 2.85, 95%CI 2.11-3.85). Patients in the control group had statistically significant odds of a longer inpatient stay (mean difference 7.79, 95%CI 6.93-8.66).\nConclusion In patients with non-acetaminophen-related acute liver failure, NAC significantly improves overall survival, post-transplant survival and transplant-free survival while decreasing the overall length of hospital stay.\nKeywords N-acetylcysteine, acute liver failure, drug-induced liver injury, acetaminophen\nAnn Gastroenterol 2021; 34 (2): 235-240" }, "format" : [ "application/pdf", "text/html" ], "identifier" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/5321", "language" : "eng", "publisher" : { "@language" : "en", "@value" : "Hellenic Society of Gastroenterology" }, "relation" : [ "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/5321/5085", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/5321/5086" ], "rights" : { "@language" : "en", "@value" : "Copyright (c) 2021 Annals of Gastroenterology" }, "source" : [ { "@language" : "en", "@value" : "Annals of Gastroenterology; Volume 34, No 2 (2021); 235" }, "1792-7463", "1108-7471" ], "subject" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "title" : { "@language" : "en", "@value" : "Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review" }, "type" : [ "info:eu-repo/semantics/article", "info:eu-repo/semantics/publishedVersion", { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part" }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article" } ], "created" : "2021-03-05" } ], "@context" : { "title" : { "@id" : "http://purl.org/dc/elements/1.1/title" }, "source" : { "@id" : "http://purl.org/dc/elements/1.1/source" }, "format" : { "@id" : "http://purl.org/dc/elements/1.1/format" }, "creator" : { "@id" : "http://purl.org/dc/elements/1.1/creator" }, "type" : { "@id" : "http://purl.org/dc/elements/1.1/type" }, "subject" : { "@id" : "http://purl.org/dc/elements/1.1/subject", "@type" : "@id" }, "relation" : { "@id" : "http://purl.org/dc/elements/1.1/relation", "@type" : "@id" }, "language" : { "@id" : "http://purl.org/dc/elements/1.1/language" }, "created" : { "@id" : "http://purl.org/dc/terms/created" }, "description" : { "@id" : "http://purl.org/dc/elements/1.1/description" }, "publisher" : { "@id" : "http://purl.org/dc/elements/1.1/publisher" }, "rights" : { "@id" : "http://purl.org/dc/elements/1.1/rights" }, "identifier" : { "@id" : "http://purl.org/dc/elements/1.1/identifier" }, "broader" : { "@id" : "http://www.w3.org/2004/02/skos/core#broader", "@type" : "@id" }, "prefLabel" : { "@id" : "http://www.w3.org/2004/02/skos/core#prefLabel" }, "provider" : { "@id" : "http://www.europeana.eu/schemas/edm/provider" }, "isShownAt" : { "@id" : "http://www.europeana.eu/schemas/edm/isShownAt", "@type" : "@id" }, "dataProvider" : { "@id" : "http://www.europeana.eu/schemas/edm/dataProvider" }, "aggregatedCHO" : { "@id" : "http://www.europeana.eu/schemas/edm/aggregatedCHO", "@type" : "@id" }, "note" : { "@id" : "http://www.w3.org/2004/02/skos/core#note" }, "exactMatch" : { "@id" : "http://www.w3.org/2004/02/skos/core#exactMatch", "@type" : "@id" }, "ore" : "http://www.openarchives.org/ore/terms/", "owl" : "http://www.w3.org/2002/07/owl#", "svcs" : "http://rdfs.org/sioc/services#", "skos" : "http://www.w3.org/2004/02/skos/core#", "rdfs" : "http://www.w3.org/2000/01/rdf-schema#", "rdaGr2" : "http://rdvocab.info/ElementsGr2/", "edm" : "http://www.europeana.eu/schemas/edm/", "ekt" : "https://www.semantics.gr/authorities/schemanamespaces/ekt#", "doap" : "http://usefulinc.com/ns/doap#", "rdf" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#", "xalan" : "http://xml.apache.org/xalan", "dcterms" : "http://purl.org/dc/terms/", "wgs84_pos" : "http://www.w3.org/2003/01/geo/wgs84_pos#", "foaf" : "http://xmlns.com/foaf/0.1/", "crm" : "http://www.cidoc-crm.org/rdfs/cidoc_crm_v5.0.2_english_label.rdfs#", "dc" : "http://purl.org/dc/elements/1.1/" } }