Soultati, AspasiaDourakis, S. P.Acute liver failure (ALF) is characterized by severe and sudden liver cell dysfunction leading to coagulopathy and hepatic encephalopathy in previously healthy persons. A critical degree of liver cell death not adequately decompensated by hepatocellular regenerative activity is fundamental to the development of ALF. Interaction between two dominant pathological pathways is illustrated as the triggering event: apoptosis and necrosis. A correlation has been demonstrated between the etiology of ALF and the dominating pathological pathway. Liver cell death signaling pathways modulated by an increasingly recognized number of tyrosine kinases, adapter molecules, transcription factors, proinflammatory and vasoactive cytokines and chemokines through both stimulating and depressant interactions have been demonstrated. What's more Systemic Inflammatory Response Syndrome whether or not precipitated by infection, appears to be implicated in the progression of encephalopathy, reducing the chances of transplantation and conferring a poorer prognosis. Hepatic encephalopathy and brain edema arising from exposure of the brain to circulating neurotoxins also signifies a serious prognosis in ALF. Key words: Fulminant Hepatic Failure, Apoptosis, Necrosis, Tumour Necrosis Factor, Systemic Inflammatory Response Syndrome, Caspases, Oxidative Stress, Hepatocellular Regeneration, Hepatic Encephalopathy, Brain Edema.application/pdfhttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/544engHellenic Society of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 19, No 4 (2006)Pathogenesis of Fulminant Hepatic Failureinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2007-04-12Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.ΑναφοράReportΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other