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      "@value" : "In the last decade significant advances in the field of IBD genetics\nhave taken place and various putative loci of genetic\nsusceptibility to IBD have been identified. Since the discovery\nin 2001 of the only confirmed Crohn's disease susceptibility\ngene (CARD15/NOD2), various other genes have been\nextensively investigated with conflicting results. Apart from\na risk haplotype in chromosome 5 no other widely confirmed\nassociations with IBD have been discovered. Pharmacogenetics\nis the study of the relation between genetic variability\nand variability in drug response or toxicity. Pharmacogenetic\nstudies examined the role of gene variations in the\ntreatment of IBD patients with sulphasalazine, mesalazine,\nmethotrexate, thiopourines, corticosteroids and infliximab\nbut the only discovery partially translated into clinical use is\nthe relation between TPMT gene polymorphisms and hematological\ntoxicity of thiopourines. At present the application\nof genetic testing in routine clinical practice for the diagnosis\nand treatment of IBD seems premature and cannot be recommended.\nPerhaps in the future a panel of genetic markers\nwill be put into clinical use in order to predict the diseases's\ncourse, complications and response to therapy.\nKey Words: ulcerative colitis, Crohn's disease, inflammatory\nbowel disease, genetics, pharmacogenetics, susceptibility\ngenes."
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