{ "@graph" : [ { "@id" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/EKT-voc-classifier/1368266523", "exactMatch" : [ "http://id.loc.gov/authorities/subjects/sh85053479", "http://semantics.gr/authorities/EKT-voc/657834409" ], "note" : { "@language" : "en", "@value" : "isi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum." }, "prefLabel" : [ { "@language" : "en", "@value" : "Gastroenterology" }, { "@language" : "el", "@value" : "Γαστροεντερολογία" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/Issue-segment", "prefLabel" : [ { "@language" : "en", "@value" : "Publication in journal" }, { "@language" : "el", "@value" : "Δημοσίευση σε περιοδικό" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/arthro", "prefLabel" : [ { "@language" : "en", "@value" : "Scientific article" }, { "@language" : "el", "@value" : "Επιστημονικό άρθρο" } ] }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/aggregation/provider/000025-6333%231", "@type" : "ore:Aggregation", "aggregatedCHO" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-6333", "dataProvider" : "Ελληνική Γαστροεντερολογική Εταιρία", "isShownAt" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6333", "provider" : "Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)", "edm:rights" : "other" }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-6333", "@type" : "edm:ProvidedCHO", "creator" : [ "Proctor, Deborah D.", "Levine, Louis J.", "Viana, Artur V.", "Gaidos, Jill K. J.", "Al-Bawardy, Badr" ], "description" : { "@language" : "en", "@value" : "Background Vedolizumab is used in inflammatory bowel disease (IBD), administered as a non-weight-based fixed dose. A higher body mass index (BMI) is associated with lower serum vedolizumab levels, but it is unclear whether it is associated with an unfavorable response to vedolizumab. We examined the relationship between BMI and the need for dose escalation, and the overall response to vedolizumab in IBD patients.\nMethods This was a single-center, retrospective study of IBD patients who received vedolizumab between 1st July 2014 and 1st September 2020. The primary outcome was need for vedolizumab dose escalation or discontinuation. Secondary outcomes were steroid-free clinical remission (SFCR), endoscopic remission, and normal serum C-reactive protein (CRP). Outcomes were compared between patients with BMI <30 kg/m2 (non-obese) or ≥30 kg/m2 (obese).\nResults 190 patients were included, with a median follow-up time of 21 months. Median age was 37 years, 50.5% were male, and median BMI was 24.8 kg/m2 (75.3% of patients had BMI <30 kg/m2). Vedolizumab was dose-escalated in 48.9% of the obese group vs. 42% of the nonobese group (P=0.4). Vedolizumab was discontinued in 31.9% of the obese group vs. 53.2% of the non-obese group (P=0.01). The rate of CRP normalization was significantly lower in the obese group (46.2% vs. 66%, P=0.03). SFCR and endoscopic remission rates were not significantly different between the groups.\nConclusions Obesity was not associated with higher rates of vedolizumab dose escalation. However, it was associated with lower rates of vedolizumab discontinuation and CRP normalization, but not SFCR or endoscopic remission.\nKeywords Inflammatory bowel diseases, obesity, vedolizumab, body mass index\nAnn Gastroenterol 2022; 35 (3): 275-280" }, "format" : [ "text/html", "application/pdf" ], "identifier" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6333", "language" : "eng", "publisher" : { "@language" : "en", "@value" : "Hellenic Society of Gastroenterology" }, "relation" : [ "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6333/5378", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6333/5377" ], "rights" : { "@language" : "en", "@value" : "Copyright (c) 2022 Annals of Gastroenterology" }, "source" : [ "1108-7471", { "@language" : "en", "@value" : "Annals of Gastroenterology; Volume 35, No 3 (2022); 275" }, "1792-7463" ], "subject" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "title" : { "@language" : "en", "@value" : "Effect of obesity on vedolizumab response in inflammatory bowel disease" }, "type" : [ "info:eu-repo/semantics/publishedVersion", { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part" }, "info:eu-repo/semantics/article", { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article" } ], "created" : "2022-05-12" } ], "@context" : { "type" : { "@id" : "http://purl.org/dc/elements/1.1/type" }, "description" : { "@id" : "http://purl.org/dc/elements/1.1/description" }, "publisher" : { "@id" : "http://purl.org/dc/elements/1.1/publisher" }, "creator" : { "@id" : "http://purl.org/dc/elements/1.1/creator" }, "identifier" : { "@id" : "http://purl.org/dc/elements/1.1/identifier" }, "subject" : { "@id" : "http://purl.org/dc/elements/1.1/subject", "@type" : "@id" }, "source" : { "@id" : "http://purl.org/dc/elements/1.1/source" }, "relation" : { "@id" : "http://purl.org/dc/elements/1.1/relation", "@type" : "@id" }, "language" : { "@id" : "http://purl.org/dc/elements/1.1/language" }, "rights" : { "@id" : "http://purl.org/dc/elements/1.1/rights" }, "format" : { "@id" : "http://purl.org/dc/elements/1.1/format" }, "created" : { "@id" : "http://purl.org/dc/terms/created" }, "title" : { "@id" : "http://purl.org/dc/elements/1.1/title" }, "provider" : { "@id" : "http://www.europeana.eu/schemas/edm/provider" }, "isShownAt" : { "@id" : "http://www.europeana.eu/schemas/edm/isShownAt", "@type" : "@id" }, "dataProvider" : { "@id" : "http://www.europeana.eu/schemas/edm/dataProvider" }, "aggregatedCHO" : { "@id" : "http://www.europeana.eu/schemas/edm/aggregatedCHO", "@type" : "@id" }, "broader" : { "@id" : "http://www.w3.org/2004/02/skos/core#broader", "@type" : "@id" }, "prefLabel" : { "@id" : "http://www.w3.org/2004/02/skos/core#prefLabel" }, "note" : { "@id" : "http://www.w3.org/2004/02/skos/core#note" }, "exactMatch" : { "@id" : "http://www.w3.org/2004/02/skos/core#exactMatch", "@type" : "@id" }, "ore" : "http://www.openarchives.org/ore/terms/", "owl" : "http://www.w3.org/2002/07/owl#", "svcs" : "http://rdfs.org/sioc/services#", "skos" : "http://www.w3.org/2004/02/skos/core#", "rdfs" : "http://www.w3.org/2000/01/rdf-schema#", "rdaGr2" : "http://rdvocab.info/ElementsGr2/", "edm" : "http://www.europeana.eu/schemas/edm/", "ekt" : "https://www.semantics.gr/authorities/schemanamespaces/ekt#", "doap" : "http://usefulinc.com/ns/doap#", "rdf" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#", "xalan" : "http://xml.apache.org/xalan", "dcterms" : "http://purl.org/dc/terms/", "wgs84_pos" : "http://www.w3.org/2003/01/geo/wgs84_pos#", "foaf" : "http://xmlns.com/foaf/0.1/", "crm" : "http://www.cidoc-crm.org/rdfs/cidoc_crm_v5.0.2_english_label.rdfs#", "dc" : "http://purl.org/dc/elements/1.1/" } }