{ "@graph" : [ { "@id" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/EKT-voc-classifier/1368266523", "exactMatch" : [ "http://id.loc.gov/authorities/subjects/sh85053479", "http://semantics.gr/authorities/EKT-voc/657834409" ], "note" : { "@language" : "en", "@value" : "isi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum." }, "prefLabel" : [ { "@language" : "en", "@value" : "Gastroenterology" }, { "@language" : "el", "@value" : "Γαστροεντερολογία" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/Issue-segment", "prefLabel" : [ { "@language" : "en", "@value" : "Publication in journal" }, { "@language" : "el", "@value" : "Δημοσίευση σε περιοδικό" } ] }, { "@id" : "http://semantics.gr/authorities/openarchives-item-types/Scientific-article", "@type" : "skos:Concept", "broader" : "http://semantics.gr/authorities/openarchives-item-types/arthro", "prefLabel" : [ { "@language" : "en", "@value" : "Scientific article" }, { "@language" : "el", "@value" : "Επιστημονικό άρθρο" } ] }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/aggregation/provider/000025-6516%231", "@type" : "ore:Aggregation", "aggregatedCHO" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-6516", "dataProvider" : "Ελληνική Γαστροεντερολογική Εταιρία", "isShownAt" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6516", "provider" : "Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)", "rights" : "other" }, { "@id" : "https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-6516", "@type" : "edm:ProvidedCHO", "creator" : [ "Samarkos, Michael", "Gyftopoulos, Argyrios", "Sipsas, Nikolaos V.", "Basoulis, Dimitrios", "Cholongitas, Evagelos", "Giannakodimos, Alexios", "Karamanakos, Georgios", "Georgakopoulou, Vasiliki E.", "Iliadi, Eirini", "Mimidis, Konstantinos", "Gerogiannis, Dimitrios", "Bali, Triada", "Georgilaki, Vasiliki" ], "description" : { "@language" : "en", "@value" : "Background Abnormalities in aminotransferases are frequently observed in hospitalized COVID-19 patients, but their clinical impact is poorly characterized.\nMethods A total of 1046 patients hospitalized to the non-intensive care unit ward with documented COVID-19 were included retrospectively. Demographic, clinical and laboratory characteristics on admission and during hospital stay, including the presence of liver injury (LI), defined as aspartate aminotransferase (AST) >200 IU/L, were recorded.\nResults On admission, 363 (34.7%) and 269 (25.7%) patients had abnormal AST and ALT values (i.e., >40 IU/L), respectively, while during hospitalization 53 (5%) patients fulfilled the criteria for LI. In multivariate logistic regression analysis, AST (odds ratio [OR] 1.023, 95% confidence interval [CI] 1.016-1.029; P<0.001), and ferritin (OR 1.01, 95%CI 1.001-1.02; P<0.001) were the baseline factors independently associated with the development of LI during hospital stay. One hundred twenty-three (11.7%) patients died during hospitalization. The independent variables associated with mortality were: age (hazard ratio [HR] 1.043, 95%CI 1.029-1.056;  <0.001),ferritin (HR 1.1, 95%CI 1.05-1.2; P<0.001), platelets (HR 0.996, 95%CI 0.994-0.999; P=0.003), and administration of remdesivir (HR 0.50, 95%CI 0.30-0.85; P=0.009). The patients with abnormal baseline AST (i.e., >40 IU/L), compared to those with normal AST values, had worse outcomes (log rank test: 8.8, P=0.003).\nConclusions Elevated aminotransferases are commonly seen in COVID-19 patients. They possibly reflect disease severity and may be associated with in-hospital mortality.\nKeywords COVID-19, liver injury, liver function tests, disease severity, mortality\nAnn Gastroenterol 2022; 35 (3): 290-296" }, "format" : [ "text/html", "application/pdf" ], "identifier" : "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6516", "language" : "eng", "publisher" : { "@language" : "en", "@value" : "Hellenic Society of Gastroenterology" }, "relation" : [ "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6516/5381", "http://www.annalsgastro.gr/index.php/annalsgastro/article/view/6516/5382" ], "dc:rights" : { "@language" : "en", "@value" : "Copyright (c) 2022 Annals of Gastroenterology" }, "source" : [ "1108-7471", "1792-7463", { "@language" : "en", "@value" : "Annals of Gastroenterology; Volume 35, No 3 (2022); 290" } ], "subject" : "http://semantics.gr/authorities/EKT-voc-classifier/657834409", "title" : { "@language" : "en", "@value" : "Prevalence of abnormal liver biochemistry and its impact on COVID-19 patients’ outcomes: a single-center Greek study" }, "type" : [ "http://semantics.gr/authorities/openarchives-item-types/Journal-part", "http://semantics.gr/authorities/openarchives-item-types/Scientific-article" ], "dc:type" : [ "info:eu-repo/semantics/article", "info:eu-repo/semantics/publishedVersion" ], "created" : "2022-05-12" } ], "@context" : { "rights" : { "@id" : "http://www.europeana.eu/schemas/edm/rights" }, "provider" : { "@id" : "http://www.europeana.eu/schemas/edm/provider" }, "isShownAt" : { "@id" : "http://www.europeana.eu/schemas/edm/isShownAt", "@type" : "@id" }, "dataProvider" : { "@id" : "http://www.europeana.eu/schemas/edm/dataProvider" }, "aggregatedCHO" : { "@id" : "http://www.europeana.eu/schemas/edm/aggregatedCHO", "@type" : "@id" }, "creator" : { "@id" : "http://purl.org/dc/elements/1.1/creator" }, "source" : { "@id" : "http://purl.org/dc/elements/1.1/source" }, "subject" : { "@id" : "http://purl.org/dc/elements/1.1/subject", "@type" : "@id" }, "type" : { "@id" : "http://purl.org/dc/elements/1.1/type", "@type" : "@id" }, "identifier" : { "@id" : "http://purl.org/dc/elements/1.1/identifier" }, "language" : { "@id" : "http://purl.org/dc/elements/1.1/language" }, "relation" : { "@id" : "http://purl.org/dc/elements/1.1/relation", "@type" : "@id" }, "title" : { "@id" : "http://purl.org/dc/elements/1.1/title" }, "publisher" : { "@id" : "http://purl.org/dc/elements/1.1/publisher" }, "description" : { "@id" : "http://purl.org/dc/elements/1.1/description" }, "format" : { "@id" : "http://purl.org/dc/elements/1.1/format" }, "created" : { "@id" : "http://purl.org/dc/terms/created" }, "broader" : { "@id" : "http://www.w3.org/2004/02/skos/core#broader", "@type" : "@id" }, "prefLabel" : { "@id" : "http://www.w3.org/2004/02/skos/core#prefLabel" }, "note" : { "@id" : "http://www.w3.org/2004/02/skos/core#note" }, "exactMatch" : { "@id" : "http://www.w3.org/2004/02/skos/core#exactMatch", "@type" : "@id" }, "ore" : "http://www.openarchives.org/ore/terms/", "owl" : "http://www.w3.org/2002/07/owl#", "svcs" : "http://rdfs.org/sioc/services#", "skos" : "http://www.w3.org/2004/02/skos/core#", "rdfs" : "http://www.w3.org/2000/01/rdf-schema#", "rdaGr2" : "http://rdvocab.info/ElementsGr2/", "edm" : "http://www.europeana.eu/schemas/edm/", "ekt" : "https://www.semantics.gr/authorities/schemanamespaces/ekt#", "doap" : "http://usefulinc.com/ns/doap#", "rdf" : "http://www.w3.org/1999/02/22-rdf-syntax-ns#", "xalan" : "http://xml.apache.org/xalan", "dcterms" : "http://purl.org/dc/terms/", "wgs84_pos" : "http://www.w3.org/2003/01/geo/wgs84_pos#", "foaf" : "http://xmlns.com/foaf/0.1/", "crm" : "http://www.cidoc-crm.org/rdfs/cidoc_crm_v5.0.2_english_label.rdfs#", "dc" : "http://purl.org/dc/elements/1.1/" } }