Gkegkes, Ioannis D.Fotiou, AlexandrosMavroeidis, Vasileios K.Gerogiannis, Ioannis N.Iavazzo, ChristosBackground Extrapelvic manifestations of endometriosis can be identified in nearly every part of the female body, and the true prevalence of extrapelvic locations is unknown. Pancreatic endometriosis may manifest in several ways, ranging from emergency presentations to asymptomatic cysts. Method A systematic PubMed and Scopus search was conducted. Results Eighteen patients from 17 case reports were included. The patients’ mean age was 39.3 (range: 21-72) years. An emergency presentation was noted in 8 of the 18 (44.4%) patients. Menstrual irregularity was present in 3 (16.7%) patients, while in 3 (16.7%) cases there was simultaneous presence of endometriosis elsewhere. The most frequent symptoms at presentation of pancreatic endometrial cysts were epigastric pain, acute left upper quadrant pain, back pain, nausea/vomiting/diarrhea, which occurred in 12 (66.7%), 11 (61.1%), 4 (22.2%), and 6 (33.3%) patients, respectively. Only one case presented as an asymptomatic pancreatic cyst. The maximum diameter of the endometrial cysts ranged from 1-16 cm. In the majority of cases, surgical treatment was offered (16/18, 88.9%). Recurrence of pancreatic endometrial cyst occurred in one case only, following needle aspiration of the endometrial cyst. No fatality was reported. Conclusions Review of the available published literature suggests that pancreatic endometriosis is a rare condition that should be included in the differential diagnosis of pancreatic masses. Further clinical and experimental studies are necessary to investigate the pathogenesis of extrapelvic and pancreatic endometriosis. Keywords Pancreas, endometriosis, endometrial cyst, abdominal mass, pancreatic endometriosis Ann Gastroenterol 2023; 36 (1): 61-67text/htmlapplication/pdfhttp://www.annalsgastro.gr/index.php/annalsgastro/article/view/6769engHellenic Society of GastroenterologyCopyright (c) 2022 Annals of Gastroenterology1792-74631108-7471Annals of Gastroenterology; Volume 36, No 1 (2023); 61Pancreatic endometriosis: a systematic reviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2022-12-25Δημοσίευση σε περιοδικόPublication in journalΓαστροεντερολογίαGastroenterologyisi -Gastroenterology & Hepatology covers resources on the anatomy, physiology, biochemistry, and pathology of the digestive system. This category includes specific resources on the prognosis and treatment of digestive diseases; stomach ulcers; metabolic, genetic, infectious and chemically induced diseases of the liver; colitis; diseases of the pancreas and diseases of the rectum.Επιστημονικό άρθροScientific articleΕλληνική Γαστροεντερολογική ΕταιρίαGreek Aggregator OpenArchives.gr | National Documentation Centre (EKT)other