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Patterns and clinical relevance of antibody responses during adalimumab therapy

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Hellenic Society of Gastroenterology   

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Annals of Gastroenterology   

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Patterns and clinical relevance of antibody responses during adalimumab therapy (EN)
Katsanos, K.H.
Vagias, I.
Tsianos, V.
Tsianos, E.V.
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
2010-07-09
All biologic therapies have the potential to induce immunogenicity. Homology reduces antigenicity, but ‘humanization' does not equate with homology and human antibodies may be also immunogenic. Despite of its proved efficacy in Crohn's disease patients, adalimumab carries the potential of molecule-specific toxicities which may be expressed with several types of antibody responses, and which are usually divided as allergic, autoimmunity and immunogenicity phenomena. (EN)
English
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 23, No 3 (2010); 165 - 171 (EN)
Hellenic Society of Gastroenterology
Annals of Gastroenterology
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