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Report (EN)

2007 (EN)
Mixed cryoglobulinemia and HCV (EN)

Papageorgiou N. Johanna,
Tassopoulos N.,

SUMMARY Mixed cryoglobulinemia (MC) is a well-documented extrahepatic manifestation of hepatitis C virus (HCV) infection. MC is a systemic vasculitis of small to medium-sized vessels due to vascular deposition of circulating immune-complexes and complement; it is characterized by the presence in the cooled serum of one or more mono- or poly-clonal immunoglobulins that precipitate at temperature below 37� C and redissolve on rewarming. MC is clinically characterized by a triad of purpura, arthralgia and asthenia and sometimes may involve peripheral nerves, the kidneys and the development of B-cell non-Hogkin's lymphoma. The discovery of the relation between HCV infection and MC shows the association between a viral infection, and an autoimmune disease and, thus, a potential link between the systemic autoimmune and lymphoproliferative disorders. The eradication of HCV, by alfa-interferon, is associated with improvement or disappearance of MC-associated clinical manifestations. Key-words: Mixed cryoglobulinemia, Hepatitis C Virus, non- Hogkin's lymphoma, interferon alfa. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 15, No 1 (2002) (EN)

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