This item is provided by the institution :

Repository :
Annals of Gastroenterology
see the original item page
in the repository's web site and access all digital files if the item*
share



Report (EN)

2007 (EN)
Mixed cryoglobulinemia and HCV (EN)

Papageorgiou N. Johanna,
Tassopoulos N.,

SUMMARY Mixed cryoglobulinemia (MC) is a well-documented extrahepatic manifestation of hepatitis C virus (HCV) infection. MC is a systemic vasculitis of small to medium-sized vessels due to vascular deposition of circulating immune-complexes and complement; it is characterized by the presence in the cooled serum of one or more mono- or poly-clonal immunoglobulins that precipitate at temperature below 37� C and redissolve on rewarming. MC is clinically characterized by a triad of purpura, arthralgia and asthenia and sometimes may involve peripheral nerves, the kidneys and the development of B-cell non-Hogkin's lymphoma. The discovery of the relation between HCV infection and MC shows the association between a viral infection, and an autoimmune disease and, thus, a potential link between the systemic autoimmune and lymphoproliferative disorders. The eradication of HCV, by alfa-interferon, is associated with improvement or disappearance of MC-associated clinical manifestations. Key-words: Mixed cryoglobulinemia, Hepatitis C Virus, non- Hogkin's lymphoma, interferon alfa. (EN)

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-03-19


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 15, No 1 (2002) (EN)



*Institutions are responsible for keeping their URLs functional (digital file, item page in repository site)