Right colonic ischemia due to factor V leiden mutation:Report of a case
A. Efthymiou, S. Dokas, E. Kivernitou, E. Molivas, D. Moliva, G. Kouklakis, H. Fronis,
The protein C anticoagulant pathway is an important downregulating
mechanism of the blood coagulation cascade.
Resistance to activated protein C (APCR) due to factor V
Leiden mutation is now recognized as the single most common
cause of hereditary thrombophilia. We report a 73-yrold
male with right colonic ischemia probably from occlusion
of small branches of the superior mesenteric artery.
Hemostasis laboratory analysis was normal except for the
resistance to activated protein C. Genetic testing revealed
that the patient was heterozygous for the factor V Leiden
mutation. APCR caused by factor V Leiden mutation should
be considered a possible etiological factor of ischemic colitis.
In a review of the associated literature, we found only
one case of ischemic colitis and two cases of ischemia of
the small intestine attributed to factor V Leiden mutation.