Right colonic ischemia due to factor V leiden mutation:Report of a case

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2007 (EN)
Right colonic ischemia due to factor V leiden mutation:Report of a case (EN)

A. Efthymiou, S. Dokas, E. Kivernitou, E. Molivas, D. Moliva, G. Kouklakis, H. Fronis,

SUMMARY The protein C anticoagulant pathway is an important downregulating mechanism of the blood coagulation cascade. Resistance to activated protein C (APCR) due to factor V Leiden mutation is now recognized as the single most common cause of hereditary thrombophilia. We report a 73-yrold male with right colonic ischemia probably from occlusion of small branches of the superior mesenteric artery. Hemostasis laboratory analysis was normal except for the resistance to activated protein C. Genetic testing revealed that the patient was heterozygous for the factor V Leiden mutation. APCR caused by factor V Leiden mutation should be considered a possible etiological factor of ischemic colitis. In a review of the associated literature, we found only one case of ischemic colitis and two cases of ischemia of the small intestine attributed to factor V Leiden mutation. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 15, No 2 (2002) (EN)

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