Current views on the use of probiotics in begnign diseases of the large intestine

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2007 (EN)
Current views on the use of probiotics in begnign diseases of the large intestine (EN)

D.G. Karamanolis, Maria Tzouvala,

SUMMARY Manipulation of the bacterial intestinal microflora with probiotics, which are living micro-organisms, appears to be an appealing therapeutic alternative for certain gastrointestinal diseases. Probiotics are considered to exert antimicrobial activities, immunomodulation and production of nutrients of special importance to the intestine. So far, most of the data on their use have been derived from the studies of the bacterium Lactobacillus casei sp rhamnosus and the non-pathogenic yeast Saccharomyces boulardii. Recent data, suggest a potential beneficial role of probiotics in reducing the severity and duration of rotavirus enteritis in children, preventing traveler’s and antibiotic-associated diarrhea, and reducing the rate of relapse of Clostridium difficile colitis. The implication of luminal bacterial flora in the pathogenesis of Inflammatory bowel disease (IBD), has been the rationale, to investigate the role of probiotics in animal models and subsequently in clinical studies. Although results are preliminary, a promising effect of these agents has been suggested in the treatment of IBD. Probiotics are currently investigated in Irritable Bowel Syndrome, as well. Ultimately, well designed, double-blind, placebo-controlled studies of efficacy, in addition to prudent assessment of safety are required, to establish the potential therapeutic role of these biologic agents in gastrointestinal diseases. Key words: Probiotics, Lactobacillus, Saccharomyces boulardii, Clostridium difficile colitis, antibiotic-associated diarrhea, traveler’s diarrhea, Inflammatory Bowel Disease, Irritable Bowel Syndrome. (EN)




Hellenic Society of Gastroenterology (EN)

Annals of Gastroenterology; Volume 16, No 2 (2003) (EN)

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