SUMMARY
All the experimental models for the induction of colon cancer
have several potential advantages, such the ability to
precisely control the animals diets and other environmental
factors, the opportunity to systematically investigate
biochemical and molecular parameters of interest during
the premalignant phase and so on. It is clear that they are
only models and that the data generated may or may not be
directly applicable to the colonic malignant transformation
processes in humans.
Key words: Chemical compounds, Carcinogens, Tumour cell
lines, Colon, Animal model
(EN)
