Advances in the development of new biologics in inflammatory bowel disease

 
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Journal part (EN)
Scientific article (EN)
2016 (EN)
Advances in the development of new biologics in inflammatory bowel disease (EN)
Ungar, Bella
Kopylov, Uri
Biologics have revolutionized the therapeutic approach in inflammatory bowel disease (IBD). Anti-tumor necrosis factor (anti-TNF) agents infl iximab and adalimumab currently constitute the major biological therapy in IBD. Additional anti-TNFs such as golimumab and other new biologics are currently being developed for both anti-TNF-naïve and -resistant patients. These include anti-integrins (vedolizumab and etrolizumab), a JAK inhibitor (tofacitinib) and an anti-anti-interleukin (IL)-23 and IL-12 antibody (ustekinumab), among additional drugs in development. The following review discusses the indications, efficacy and safety issues for these novel medications.Keywords Infl ammatory bowel disease, Crohn's disease, ulcerative colitis, therapy, biologicsAnn Gastroenterol 2016; 29 (3): 243-248 (EN)
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Hellenic Society of Gastroenterology
Annals of Gastroenterology
Invited Review
English
2016-06-27
http://www.annalsgastro.gr/index.php/annalsgastro/article/view/2591
Hellenic Society of Gastroenterology (EN)
1792-7463
1108-7471
Annals of Gastroenterology; Volume 29, No 3 (2016); 243 (EN)



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