Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE): an international, multicenter consortium for the study of acute pancreatitis

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Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE): an international, multicenter consortium for the study of acute pancreatitis (EN)

Goenka, Mahesh Kumar
Greer, Phil J.
Machicado, Jorge D.
Barbu, Sorin T.
Nawaz, Haq
Capurso, Gabriele
Tiwari, Subhash Ch.
Cote, Gregory A.
Kamal, Ayesha
Singh, Vikesh K.
Zarnescu, Narcis O.
Koutroumpakis, Efstratios
Akshintala, Venkata
Ferreira, Miguel
Ocampo, Carlos
Gulla, Aiste
Archibugi, Livia
Gougol, Amir
de-Madaria, Enrique
Triantafyllou, Konstantinos
Papachristou, Georgios I.
Gonzalez-Gonzalez, Jose A.
Gutierrez, Silvia C.
Lambiase, Louis
Dugum, Mohannad
Chua, Tiffany
Wu, Benchien U.
Park, Walter G.
Kochhar, Rakesh
Easler, Jeffrey
Lee, Peter J.
Pelaez-Luna, Mario
Stevens, Tyler

Background We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials.Methods The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients.Results Between November 2015 and September 2016, a total of 20 sites (8 in the United States, 5 in Europe, 3 in South America, 2 in Mexico and 2 in India) prospectively enrolled 509 AP patients. All data were entered into the REDCap (Research Electronic Data Capture) database by participating centers and systematically reviewed by the coordinating site (University of Pittsburgh). The approaches and methodology are described in detail, along with an interim report on the demographic results.Conclusion APPRENTICE, an international collaboration of tertiary AP centers throughout the world, has demonstrated the feasibility of building a large, prospective, multicenter patient registry to study AP. Analysis of the collected data may provide a greater understanding of AP and APPRENTICE will serve as a future platform for randomized clinical trials.Keywords Acute pancreatitis, international multicenter consortium, methodology, APPRENTICEAnn Gastroenterol 2017; 30 (1): 106-113 (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2016-12-27


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 30, No 1 (2017); 106 (EN)



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