Non-alcoholic fatty liver disease: controlling an emerging epidemic, challenges, and future directions

 
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2018 (EN)
Non-alcoholic fatty liver disease: controlling an emerging epidemic, challenges, and future directions (EN)

Ofosu, Andrew
Ramai, Daryl
Reddy, Madhavi

Non-alcoholic fatty liver disease (NAFLD) affects over 30% of the United States population and is projected to become a leading cause of chronic liver disease by 2020. As a result, the economic and societal burden of NAFLD is far-reaching. The cost of managing NAFLD complications has an estimated 10 year economic burden of $908 billion. This review provides an overview of current knowledge on NAFLD, with emphasis on identifying gaps in its diagnosis and management, and proposes future directions to address these limitations. Despite the increasing prevalence of NAFLD, there is limited knowledge and practice regarding its natural history, staging, diagnosis, and management. Though a challenging task, opportunities for bridging these gaps should focus on the development of noninvasive biomarkers, the elucidation of biological pathways, the creation of up-to-date screening guidelines, and the organization of clinical trials of longer duration to determine clinical endpoints and assess the safety of new treatment options. Keywords Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver transplantation, cirrhosis Ann Gastroenterol 2018; 31 (3): 288-295 (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2018-05-02


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 31, No 3 (2018); 288 (EN)

Copyright (c) 2018 Annals of Gastroenterology (EN)



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