Extraintestinal manifestations of Inflammatory Bowel Diseases: Is there effective liver therapy?

 
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2007 (EN)
Extraintestinal manifestations of Inflammatory Bowel Diseases: Is there effective liver therapy? (EN)

Vlachogiannakos, J.

Hepatobiliary diseases are common in IBD patients, including primary sclerosing cholangitis, sclerosing cholangitis of the small bile ducts, cirrhosis, cholangiocarcinoma, fatty liver and cholelithiasis. PSC is the most common of these diseases, with an incidence ranging from 2.5% to 7.5%. It usually progresses insidiously and finally leads to cirrhosis independent of inflammatory bowel disease activity. The probability of cholangiocarcinoma is very high in PSC patients and the prognosis is dismal. There is an elevated risk of developing colon cancer in patients with PSC. Medical therapy has not proven successful in slowing disease progression or prolonging survival in PSC. Endoscopic therapy is recommended for treating complications of recurrent cholangitis or worsening jaundice in cases of dominant stricture, but these approaches have not been definitely demonstrated to improve survival or decrease the need for liver transplantation. Liver transplantation remains the therapy of choice for patients with advanced liver disease. (EN)

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Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Society of Gastroenterology (EN)

2007-04-05


Hellenic Society of Gastroenterology (EN)

1792-7463
1108-7471
Annals of Gastroenterology; Volume 19, No 2 (2006) (EN)



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