Serum apoptotic caspase activity as a marker of severity in chronic hepatitis C virus infection

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Serum apoptotic caspase activity as a marker of severity in chronic hepatitis C virus infection (EN)

Papatheodoridis, G.V.
Manesis, E.K.
Hadziyannis, Emilia
Georgiou, Anastasia.
Archimandritis, A.J.
Tsochatzis, E.
Manolakopoulos, S.
Kafiri, Georgia.

Background & Aim: Apoptotic caspases are substantially activated in liver of patients with chronic hepatitis C and preliminary data suggest that serum caspase activity may represent a sensitive marker of early liver injury. We investigated whether the serum levels of caspase-generated fragments of cytokeratin-18 are associated with the severity of liver histological lesions in chronic hepatitis C virus (HCV) infection. Methods: We included 134 patients with chronic HCV infection who consecutively underwent liver biopsy as well as 30 healthy controls. Histological liver lesions were evaluated according to the Ishak’s classification. Chronic hepatitis C was considered to be present in cases with grading score ≥4 and/or stage ≥2, while cases with grading score (EN)

Ελληνική Γαστροεντερολογική Εταιρία (EL)
Hellenic Gastroenterologiki Company (EN)

2008-07-10


Annals of Gastroenterology (EN)

Annals of Gastroenterology; Volume 21, No 1 (2008); 39-44 (EN)



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