Roussis, VassiliosVagias, ConstantinosAlexi, XanthippiΑλέξης, Μιχαήλ Ν.Ioannou, EfstathiaAbdel-Razik, Ayman F.OXFORDFour new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.Adobe PDF4537-454110.1016/j.bmc.2009.05.004https://hdl.handle.net/10442/122440968-0896engPergamon© 2009 Elsevier Ltd. All rights reserved.© 2009 Elsevier Ltd. All rights reserved.Bioorganic & Medicinal ChemistryAntiproliferative activityEunicella cavoliniChemistry, MedicinalStructure elucidation9,11-Secosterols9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavoliniΆρθρο σε επιστημονικό περιοδικό2009-07-01Δημοσίευση σε περιοδικόPublication in journalΟργανική χημείαOrganic Chemistryisi - Chemistry, Organic includes resources that focus on synthetic and natural organic compounds their synthesis, structure, properties, and reactivity. Research on hydrocarbons, a major area of organic chemistry, is included in this category.Φαρμακευτική χημείαMedicinal chemistryisi - Chemistry, Medicinal includes resources emphasizing the isolation and study of substances with therapeutic potential. Topics of interest are quantitative structure-function relationships, structural characterization and organic syntheses of naturally occurring compounds, and chemical and analytical techniques used in rational drug design. See also the PHARMACOLOGY & PHARMACY category.Φαρμακολογία και ΦαρμακευτικήPharmacology and Pharmacyisi - Pharmacology & Pharmacy covers resources on the discovery and testing of bioactive substances, including animal research, clinical experience, delivery systems, and dispensing of drugs. This category also includes resources on the biochemistry, metabolism, and toxic or adverse effects of drugs.ΒιολογίαBiological sciencesFrascati 42Επιστημονικό άρθροScientific articleΕθνικό Ίδρυμα Ερευνών (ΕΙΕ)Greek Aggregator OpenArchives.gr | National Documentation Centre (EKT)